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M94A2885.TXT
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1994-10-25
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Document 2885
DOCN M94A2885
TI Magnesium level and peripheral neuropathy.
DT 9412
AU Stroud S; Salvato P; Thompson C; Med. Univ., Charleston, SC.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):202 (abstract no. PB0235). Unique
Identifier : AIDSLINE ICA10/94369690
AB OBJECTIVE: To determine if a relationship exists between low serum
magnesium (Mg) levels and symptoms characteristic of peripheral
neuropathy. METHODS: 68 pts. with HIV infection (59 AIDS) provided data.
Histories were compatible with sensory dysfunction. Physical exams
revealed abnormal sensory findings in feet/legs, reduced pinprick and
vibratory sensations, with reduced/absent ankle jerks. 46 pts. had EMG
nerve studies: 38 showed peripheral neuropathy. Exclusions: neurotoxic
drugs, alcohol abuse, and diabetes. All pts. had normal vitamin B12
levels, normal thyroid function, and decreased serum Mg levels (mean
1.2). Pts. received an initial IV replacement of Mg and subsequent oral
replacement. Mg levels were drawn monthly. RESULTS: Response was
measured by improved pinprick and vibratory sensation, increased ankle
jerk, decreased subjective pain, and decreased pain medication. 46 pts.
(78%) had improvement in symptoms within 24-48 hours. 22 pts. (32%)
showed no initial improvement. 7 of the 22 (32%), however, showed
improvement after subsequent oral Mg (mean 14 days). At 12 months, 13
pts. were lost to follow-up. The remaining 55 pts. (81%) continued to
demonstrate improvement in symptoms. CONCLUSIONS: Mg deficiency is a
cause of sensory peripheral neuropathy-like symptoms in HIV disease. Mg
replacement appears to be a beneficial treatment for sensory
neuropathics in late stage HIV disease, both reducing morbidity and
decreasing use of pain medications. Mg levels should be evaluated in HIV
patients presenting with sensory neuropathy.
DE Human HIV Infections/BLOOD/*COMPLICATIONS Magnesium/BLOOD/THERAPEUTIC
USE Magnesium Deficiency/*COMPLICATIONS Peripheral Nervous System
Diseases/*BLOOD/DRUG THERAPY/ETIOLOGY Sensation Disorders/BLOOD/DRUG
THERAPY/ETIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).